Patients w/ repeated or unexplained muscle aches or pains; personal or family history of muscle problems, or previous history of muscle problems w/ other cholesterol-lowering medicines; impairment of thyroid gland function; severe resp failure; patients feeling unwell, w/ fever or w/ constant muscle weakness; patients who consume excessive quantities of alcohol; Asian patients. Perform liver function tests prior to treatment & thereafter when clinically indicated. Rare reports of cognitive impairment (eg, memory loss, forgetfulness, amnesia, memory impairment, confusion) associated w/ statin use. Reports of increases in HbA1c & fasting serum glucose levels w/ HMG-CoA reductase inhibitor. Medication w/ fusidic acid (orally or by inj) in the last 7 days. Concomitant use w/ medicines for HIV eg, ritonavir w/ lopinavir &/or atazanavir; fibrates. Intolerance to some sugars. Patients w/ renal or hepatic impairment. Elderly >70 yr.